The latest research from Kitasato University, Japan

Cardiovascular disease is the number one cause of death worldwide, and restoring coronary blood flow as soon as possible after myocardial infarction is the most valuable means of treatment. But restoring blood flow after myocardial infarction can lead to ischemia-reperfusion injury, which can also lead to patient death. Oxidative stress after acute ischemia-reperfusion can cause severe tissue damage.

Kitasato University in Japan has conducted a study and achieved good results. The purpose of this study is to explore the protective and therapeutic effects of hydrogen as an antioxidant on oxidative damage of cardiomyocytes.

Kitasato University is a famous and unique medical university in Minato, Tokyo. Recently, the Kitasato University Takahito SONOBE (Kohito Garden Department) and others published a study on the protection of heart cells by hydrogen.

Experiment procedure:
First determine the toxicity of the dose of antimycin a on H9c2 cells, and found that there is a dose-effect relationship in the range of 0-500 micromol/l. The maximum dose of 500 M antimycin a treatment for 1 hour reduced the number of cells to 76.5 ± 4%. Pre-culture with 2% hydrogen for 18 hours can protect this damage and increase the cell survival rate to 159.3±9%. The research results suggest that hydrogen can protect the cell damage induced by antimycin a.

Cardiovascular disease is the most important cause of death in humans. Arteriosclerosis is the most important chronic risk factor for cardiovascular disease, and it is an important cause of myocardial ischemia and myocardial infarction caused by thrombosis leading to acute blood flow interruption in the heart. Ischemic heart disease is the disease with the highest mortality and disability rate in humans, and is the most important health problem worldwide.

Around world, acute myocardial infarction will cause more than 17.3 million deaths each year, and it is expected to increase to 23.6 million by 2030. The only effective treatment strategy for myocardial infarction is to restore perfusion, but reperfusion itself can also cause aggravation of tissue damage and even lead to patient death. The causes of myocardial reperfusion injury involve multiple processes. A large amount of research evidence shows that oxidative stress caused by the massive release of reactive oxygen species caused by reperfusion is the key factor. Controlling the production of reactive oxygen species and oxidative stress is an ideal strategy to reduce ischemia-reperfusion injury.

The study found:Molecular Hydrogen Generator is a new type of biological antioxidant. In 2007, Professor Naruo Ota had discovered that hydrogen has a very good protective effect on brain tissue ischemia-reperfusion injury. This discovery caused a large number of scholars to follow up and found that hydrogen has a variety of effects. Tissues, such as heart and liver ischemia-reperfusion injury, have a protective effect. This latest study found the protective effect of PEM H2 Machine on the oxidative damage of cardiomyocytes caused by mitochondrial complex III inhibitor antimycin a.

Myocardial ischemia is a common pathophysiological process of various heart disease states. For example, coronary atherosclerosis, acute myocardial infarction and heart transplantation all have the problem of cardiac ischemia. But the cost of treating these diseases is very high, so it is still very important to find economical treatments.

H2 Inhalation Machine is a very affordable treatment method with good effect and low cost. As a medical gas, hydrogen has outstanding advantages such as safety, economy, convenient use, selective anti-oxidation, and strong diffusivity. Hydrogen plays an important role in protecting myocardial cells and protecting heart health!